Laboratório de Neurociência Translacional

EQUIPE

PROJETOS

ARTIGOS

NOVIDADES

 

Artigos:

2024

Adenosine A2A signaling in mood disorders: how far have we come? Bevilacqua, LM, da Silveira Neto, F., Kaster MP. IBRO Neuroscience Reports, in press, 2024. 

Impact of Coffee Intake on Measures of Wellbeing in Mice. Machado NJ, Ardais AP, Nunes A, Szabó EC, Silveirinha V, Silva HB, Kaster MP, Cunha RA.  Nutrients. 2024 Sep 1;16(17):2920. doi: 10.3390/nu16172920.

Amygdala-specific changes in Cacna1c, Nfat5, and Bdnf expression are associated with stress responsivity in mice: A possible mechanism for psychiatric disorders. Bastos CR, Bevilacqua LM, Mendes LFB, Xavier J, Gruhn K, Kaster MP, Ghisleni G. J Psychiatr Res. 2024 May 10;175:259-270. doi: 10.1016/j.jpsychires.2024.05.019.

Circulating myeloid-derived MMP8 in stress susceptibility and depression. Cathomas F, Lin HY, Chan KL, Li L, Parise LF, Alvarez J, Durand-de Cuttoli R, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wilk CM, Kaster MP, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ.  Nature. 2024 Feb 7. doi: 10.1038/s41586-023-07015-2.

Depicting the molecular features of suicidal behavior: a review from an “omics” perspective. Pereira CA, Reis-de-Oliveira G, Pierone BC, Martins-de-Souza D, Kaster MP.  Psychiatry Res. 2024 Feb;332:115682. doi: 10.1016/j.psychres.2023.115682.

 

2023

Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour. Russo S, Chan K, Li L, Parise L, Cathomas F, LeClair K, Shimo Y, Lin HY, Durand-de Cuttoli R, Aubry A, Alvarez J, Drescher T, Osman A, Yuan C, Fisher-Foye R, Price G, Schmitt Y, Kaster M, Furtado GC, Lira S, Wang J, Han W, de Araujo I.  Res Sq [Preprint]. 2023 Oct 27:rs.3.rs-3459170. doi: 10.21203/rs.3.rs-3459170/v1.

Behavioral flexibility impacts on coping and emotional responses in male mice submitted to social defeat stress. Rosado AF, Bevilacqua LM, Moreira ELG, Kaster MP. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110696. 

BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity. Bastos CR, Xavier J, Camerini L, Dewes SS, Moreira FP, Wiener CD, Jansen K, Kaster MP, de Mattos Souza LD, da Silva RA, Oses JP, Portela LV, Lara DR, Tovo-Rodrigues L, Ghisleni G. Cell Mol Neurobiol. 2023 Jan;43(1):357-366. 

2022

Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test. Ramos-Hryb AB, Pazini FL, Costa AP, Cunha MP, Kaster MP, Rodrigues ALS. J Pharm Pharmacol. 2022 Jan 5;74(1):13-21.

Cross-cultural adaptation and psychometric evaluation of the Brazilian version of the Temporal Experience of Pleasure Scale (TEPS-Br). Rosar PA, Traebert J, Kaster MP, Bello AF, Haviaras AC, Gard DE, Diaz AP. Trends Psychiatry Psychother. 2022 Apr 27;44:e20200131. 

2021

Sex-dependent role of CD300f immune receptor in generalized anxiety disorder. Kaufmann FN, Lago N, Alí-Ruiz D, Jansen K, Souza LDM, Silva RA, Lara DR, Ghisleni G, Peluffo H, Kaster MP.

Glibenclamide treatment prevents depressive-like behavior and memory impairment induced by chronic unpredictable stress in female mice. Rosado AF, Rosa PB, Platt N, Pierone BC, Neis VB, Severo Rodrigues AL, Kaster MP, Kaufmann FN. Behav Pharmacol. 2021.

Physical exercise prevents amyloid β1-40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice. Rosa JM, Camargo A, Wolin IAV, Kaster MP, Rodrigues ALS. Metab Brain Dis. 2021.

2020

Stress and signaling pathways regulating autophagy: From behavioral models to psychiatric disorders. Pierone BC, Pereira CA, Garcez ML, Kaster MP. Exp Neurol. 334:113485, 2020.

CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness. Lago N, Kaufmann FN, Negro-Demontel ML, Alí-Ruiz D, Ghisleni G, Rego N, Arcas-García A, Vitureira N, Jansen K, Souza LM, Silva RA, Lara DR, Pannunzio B, Abin-Carriquiry JA, Amo-Aparicio J, Martin-Otal C, Naya H, McGavern DB, Sayós J, López-Vales R, Kaster MP, Peluffo H. Proc Natl Acad Sci U S A. 117(12):6651-6662, 2020. 

Agmatine potentiates antidepressant and synaptic actions of ketamine: Effects on dendritic arbors and spines architecture and Akt/S6 kinase signaling. Freitas AE, Heinrich IA, Moura TM, Fraga DB, Costa AP, Azevedo D, Brocardo PS, Kaster MP, Leal RB, Rodrigues ALS. Exp Neurol. 333:113398, 2020.

Temperament traits moderate the relationship between Childhood Trauma and Interleukin 1β profile in young adults. Bock BB, Bastos CR, Ardais AP, Grellert M, de Carvalho HW, Farias CP, Jansen K, Oses JP, da Silva RA, Portela LV, Kaster MP, Lara DR, Ghisleni G. Psychoneuroendocrinology. 116:104671, 2020. 

Inosine prevents hyperlocomotion in a ketamine-induced model of mania in rats. Camerini L, Ardais AP, Xavier J, Bastos CR, Oliveira S, Soares MSP, de Mattos BDS, Ávila AA, do Couto CAT, Spanevello RM, Pochmann D, Moritz CEJ, Porciúncula LO, Figueiró F, Kaster MP, Ghisleni G. Brain Res. 1733:146721, 2020.

2019

Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases. Ramos-Hryb AB, Platt N, Freitas AE, Heinrich IA, López MG, Leal RB, Kaster MP, Rodrigues ALS. Neurochem Res. 2019.

Leptin polymorphism rs3828942: risk for anxiety disorders? Salerno PSV, Bastos CR, Peres A, Ardais AP, Gazal M, Jansen K, Souza LDM, da Silva RA, Kaster MP, Lara DR, Ghisleni G. Eur Arch Psychiatry Clin Neurosci. 2019. 

Potential Role of Vitamin D for the Management of Depression and Anxiety. Casseb GAS, Kaster MP, Rodrigues ALS. CNS Drugs. 33(7):619-637, 2019. 

Levels of 25-hydroxyvitamin D3, biochemical parameters and symptoms of depression and anxiety in healthy individuals. Casseb GAS, Ambrósio G, Rodrigues ALS, Kaster MP. Metab Brain Dis. 34(2):527-535, 2019. 

Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study. Oliveira S, Ardais AP, Bastos CR, Gazal M, Jansen K, de Mattos Souza L, da Silva RA, Kaster MP, Lara DR, Ghisleni G. Purinergic Signal. 15(1):37-44, 2019. 

2018

Depression and peripheral inflammatory profile of patients with obesity. Ambrósio G, Kaufmann FN, Manosso L, Platt N, Ghisleni G, Rodrigues ALS, Rieger DK, Kaster MP. Psychoneuroendocrinology. 91:132-141, 2018.

 

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway. Tavares MK, Dos Reis S, Platt N, Heinrich IA, Wolin IAV, Leal RB, Kaster MP, Rodrigues ALS, Freitas AE. Neurochem Int. 118:275-285, 2018.

2017

MACHADO, N. J. ; ARDAIS, A. P. ; KASTER, M. P. ; GARCAO, P. ; SILVA, H. B. ; RODRIGUES, D. I. ; SIMOES, A. P. ; POCHMANN, D. ; SANTOS, A. I. ; PORCIUNCULA, L. O. ; TOME, A. R. ; KOFALVI, A. ; ARAUJO, I. ; AGOSTINHO, P. M. ; VAUGEOIS, J. ; EL-YACOUBI, M. ; CUNHA, R.A. ; GOMES, C. V. . Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. MOLECULAR NEUROBIOLOGY, v. 54, p. 1552-1563, 2017.

OLIVEIRA, PATHISE SOUTO ; GAZAL, MARTA ; FLORES, NATÁLIA PORTO ; ZIMMER, ALINE RIGON ; CHAVES, VITOR CLASEN ; REGINATTO, FLÁVIO HENRIQUE ; Kaster, Manuella Pinto ; TAVARES, REJANE GIACOMELLI ; SPANEVELLO, ROSELIA MARIA ; LENCINA, CLAITON LEONETI ; STEFANELLO, FRANCIELI MORO . Vaccinium virgatum fruit extract as an important adjuvant in biochemical and behavioral alterations observed in animal model of metabolic syndrome. Biomedicine & Pharmacotherapy, v. 88, p. 939-947, 2017.

KAUFFMANN, F. N. ; COSTA, A. P. ; GHISLENI, G. ; DIAS, A. P. ; RODRIGUES, A. L. S. ; PELUFFO, H. ; KASTER, M.P. . Nlrp3 Inflammasome-Driven Pathways In Depression: Clinical And Preclinical Findings. BRAIN BEHAVIOR AND IMMUNITY, v. S0889-, p. 30064-30068, 2017.

RAMOS-HRYB, A. B. ; CUNHA, M. P. ; PAZINI, F. L. ; LIEBERKNECHT, V. ; PREDIGER, R. D. ; KASTER, M. P. ; RODRIGUES, A.L.S. . Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2. Pharmacological Reports, v. 69, p. 1240-1246, 2017.

GONCALVES, F. M. ; NEIS, V. B. ; VENSKE, D. K. R. ; PERES, T. V. ; LOPES, M. W. ; HEINRICH, I. A. ; COSTA, A. P. ; RODRIGUES, A.L.S. ; KASTER, M. P. ; LEAL, R.B. . Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test. JOURNAL OF NEURAL TRANSMISSION, v. 124, p. 1227-1237, 2017.

RAMOS-HRYB, A. B. ; PAZINI, F. L. ; KASTER, M. P. ; RODRIGUES, A.L.S. . Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases. CNS DRUGS, v. 31, p. 1029-1041, 2017.

2016

GAZAL, MARTA ; JANSEN, KAREN ; SOUZA, LUCIANO D. ; OSES, JEAN P. ; MAGALHÃES, PEDRO V. ; PINHEIRO, RICARDO ; GHISLENI, GABRIELE ; QUEVEDO, LUCIANA ; KASTER, MANUELLA P. ; KAPCZINSKI, FLÁVIO ; SILVA, RICARDO A. DA . Association of interleukin-10 levels with age of onset and duration of illness in patients with major depressive disorder. Revista Brasileira de Psiquiatria (Sao Paulo.1999.Impresso), v. 37, p. 296-302, 2016.

KASTER, MANUELLA P.; MORETTI, MORGANA ; CUNHA, MAURICIO P. ; Rodrigues, Ana Lúcia S. . Novel approaches for the management of depressive disorders. European Journal of Pharmacology, v. 771, p. 236-240, 2016.

KAUFFMANN, F. N. ; GAZAL, M. ; BASTOS, C. ; KASTER, M. P. ; GHISLENI, G. . Curcumin in depressive disorders: An overview of potential mechanisms, preclinical and clinical findings. European Journal of Pharmacology, v. 784, p. 192-198, 2016.

SIMOES, A. P. ; MACHADO, N. J. ; GONCALVES, N. ; KASTER, M.P. ; SIMOES, A. T. ; NUNES, A. Q. ; ALMEIDA, L. P. ; GOOSENS, K. A. ; RIAL, D. ; CUNHA, R.A. . Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory. NEUROPSYCHOPHARMACOLOGY, v. 41, p. 2862-2871, 2016.

DEBOM, GABRIELA ; GAZAL, MARTA ; SOARES, MAYARA SANDRIELLY PEREIRA ; DO COUTO, CARLUS AUGUSTU TAVARES ; MATTOS, BRUNA ; LENCINA, CLAITON ; Kaster, Manuella Pinto ; GHISLENI, GABRIELE CODENONZI ; TAVARES, REJANE ; BRAGANHOL, ELIZANDRA ; CHAVES, VITOR CLASEN ; REGINATTO, FLÁVIO HENRIQUE ; STEFANELLO, FRANCIELI ; SPANEVELLO, ROSELIA MARIA . Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine. Brain Research Bulletin, v. 16, p. 30352-30355, 2016.

GONCALVES, F. M. ; NEIS, V. B. ; RIEGER, D. K. ; LOPES, M. W. ; HEINRICH, I. A. ; COSTA, A. P. ; RODRIGUES, A. L. S. ; KASTER, M. P. ; LEAL, R.B. . Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signalling, v. 13, p. 203-214, 2016.